Sansom Institute, University of South Australia, South Australia, Australia.
Biomarkers. 2009 Dec;14(8):596-603. doi: 10.3109/13547500903183962.
An autism spectrum disorder (ASD) diagnosis is based on clinical behaviours as there are no validated biological diagnostic tools. Indolyl-3-acryloylglycine (IAG) is a chemical produced by gut microflora and there are conflicting reports as to whether urinary levels are elevated in children with ASD compared with controls. Urinary IAG levels in morning urine samples were statistically significantly higher in children with ASD whose caregivers reported the presence of chronic gastrointestinal (GI) disturbance than children with ASD without chronic GI disturbance. Urinary IAG, however, was not statistically significantly higher in children with ASD, compared with siblings or unrelated controls without ASD.
自闭症谱系障碍（ASD）的诊断基于临床行为，因为目前没有经过验证的生物学诊断工具。吲哚基-3-丙烯酰基甘氨酸（IAG）是一种由肠道微生物群产生的化学物质，关于自闭症儿童与对照组相比，尿液中的水平是否升高，有相互矛盾的报告。与没有慢性胃肠道（GI）紊乱的自闭症儿童相比，报告存在慢性 GI 紊乱的自闭症儿童的早晨尿液样本中的尿 IAG 水平在统计学上显著更高。然而，与没有 ASD 的兄弟姐妹或无关对照组相比，自闭症儿童的尿 IAG 水平并没有统计学上的显著升高。
