Belek A S
Hacettepe Universitesi, Tip Fakültesi, Mikrobiyoloji Anabilim Dali, Ankara.
Mikrobiyol Bul. 1992 Jan;26(1):90-6.
The great variety of cells and molecules observed in the mammalian immune system can be explained by stepwise acquisition of them during phylogeny. Self/nonself discrimination and cell-mediated immunity have been present since the early stages of evolution. Although some inducible antimicrobial molecules have been demonstrated in invertebrates, immunoglobulins appear in vertebrates. T and B cell diversity, development of the lymphoid organs, MHC molecules, complement and cytokines are the characteristics that appear through the evolution of vertebrates. Further knowledge that will be obtained from phylogenetic studies will improve our understanding of the immune system of human.
哺乳动物免疫系统中观察到的细胞和分子种类繁多，可以通过它们在系统发育过程中的逐步获得来解释。自进化早期以来就存在自我/非自我识别和细胞介导的免疫。虽然在无脊椎动物中已证明一些可诱导的抗菌分子，但免疫球蛋白出现在脊椎动物中。T细胞和B细胞的多样性、淋巴器官的发育、MHC分子、补体和细胞因子是脊椎动物进化过程中出现的特征。从系统发育研究中获得的进一步知识将增进我们对人类免疫系统的理解。
