Ertresvåg J M, Zwart J-A, Helde G, Johnsen H-J, Bovim G
Department of Neurology and Clinical Neurosphysiology, St Olavs University Hospital, Trondheim, Norway.
Acta Neurol Scand. 2005 Apr;111(4):233-7. doi: 10.1111/j.1600-0404.2005.00350.x.
The main purpose of the present prospective study was to evaluate the course of migraine and non-migrainous headache during pregnancy and to estimate the occurrence of self-reported transient focal neurological symptoms.
In total 1631 (77%) pregnant women completed the study and were followed-up during pregnancy. The first questionnaire (Q1) was sent together with the appointment letter and delivered at the time of ultrasound screening. The second questionnaire (Q2), to be filled in during pregnancy, was delivered at the time of birth. Q1 and Q2 covered questions about headache, transient neurological symptoms, and other background and demographic data. Subjects reporting transient sensory, motor or visual disturbances were also interviewed by phone in order to achieve a more precise description of the symptoms.
A total of 58% subjects with migraine reported not having migraine or no headache at all during pregnancy. Among individuals with non-migrainous headache 25% reported not having any headaches, while 1.9% of the subjects without headache experienced headache attacks during pregnancy that fulfilled the criteria for migraine. Individuals without headache or with non-migrainous headache reported significantly less sensory, motor and visual disturbances during pregnancy compared with migraine subjects. More than 60% of those with possible aura phenomenon were migraine patients, while symptoms of peripheral or non-neurological origin were more common among headache free or those with non-migrainous headache.
Transient neurological symptoms were less common among individuals without or with non-migrainous headache compared with migraine. This may indicate that there is an increased susceptibility of unknown cause for these symptoms among migraine patients during pregnancy.
本前瞻性研究的主要目的是评估偏头痛和非偏头痛性头痛在孕期的病程，并估计自我报告的短暂性局灶性神经症状的发生率。
共有1631名（77%）孕妇完成了本研究，并在孕期接受随访。第一份问卷（Q1）随预约信一同发出，在超声筛查时发放。第二份问卷（Q2）在孕期填写，在分娩时发放。Q1和Q2涵盖了有关头痛、短暂性神经症状以及其他背景和人口统计学数据的问题。对于报告有短暂性感觉、运动或视觉障碍的受试者，还通过电话进行了访谈，以便更精确地描述症状。
共有58%的偏头痛患者报告在孕期没有偏头痛或根本没有头痛。在非偏头痛性头痛患者中，25%报告没有任何头痛，而在无头痛的受试者中，1.9%在孕期经历了符合偏头痛标准的头痛发作。与偏头痛患者相比，无头痛或有非偏头痛性头痛的受试者在孕期报告的感觉、运动和视觉障碍明显更少。超过60%有可能出现先兆现象的患者为偏头痛患者，而周围性或非神经源性症状在无头痛或有非偏头痛性头痛的患者中更为常见。
与偏头痛患者相比，无头痛或有非偏头痛性头痛的个体中短暂性神经症状较少见。这可能表明偏头痛患者在孕期这些症状的易感性增加，原因不明。
