Landtblom A-M, Riise T, Kurtzke J F
Division of Neurology, University Hospital, Linköping, Sweden.
Acta Neurol Scand. 2005 Apr;111(4):238-46. doi: 10.1111/j.1600-0404.2005.00395.x.
The geographic distribution of multiple sclerosis (MS) in Sweden over time was compared in order to analyze homogeneity.
The distribution of MS was compared among three nationwide resources: 1301 hospital cases 1925-1934; 5425 deaths 1952-1992; and 11,371 disability pension recipients 1971-1994.
Distributions by county (lan) were markedly non-homogenous, with greatest variations in the early prevalence series (16-232% of the national mean), less within the death data (75-170%), and least for the disability series (87-128%). Maximal rates for MS in the early prevalence series were found for the cluster of seven counties surrounding the two major lakes of south central Sweden, as well as for one region on the northern shore of the Bay of Bothnia, and another also off the Bay north of Stockholm.
Though the epidemiologic sources are quite different, they are internally consistent and thus provide three consecutive cross-sectional views of the distribution over time. When considered together the data may be compatible with a thesis of the origin and spread of MS within Sweden from the south-central inland lake regions of the country. Such spread within a half century is too rapid for a genetic cause, including HLA patterns.
比较瑞典多发性硬化症（MS）随时间的地理分布情况，以分析其同质性。
比较了三种全国性资源中MS的分布情况：1925 - 1934年的1301例医院病例；1952 - 1992年的5425例死亡病例；以及1971 - 1994年的11371名残疾抚恤金领取者。
按郡（lan）划分的分布明显不均一，早期患病率系列差异最大（为全国均值的16% - 232%），死亡数据中的差异较小（75% - 170%），残疾系列的差异最小（87% - 128%）。在瑞典中南部两大湖泊周边的七个郡集群，以及波的尼亚湾北岸的一个地区和斯德哥尔摩以北海湾附近的另一个地区，发现了早期患病率系列中MS的最高发病率。
尽管流行病学来源差异很大，但它们内部是一致的，因此提供了随时间分布的三个连续横断面视图。综合考虑这些数据可能与MS在瑞典境内从中南部内陆湖泊地区起源和传播的论点相符。在半个世纪内如此迅速的传播对于包括HLA模式在内的遗传原因来说太快了。
