Sharma Niti, Sharma Vinay K, Seo Sung-Yum
Applied Biotechnology Laboratory, Department of Biology, College of Natural Science, Kongju National University, Kongju 314-701, Korea.
J Ethnopharmacol. 2005 Mar 21;97(3):453-6. doi: 10.1016/j.jep.2004.11.009.
In order to find new pancreatic lipase (triacylglycerol lipase, EC 3.1.1.3) inhibitors from natural sources, 75 medicinal plants belonging to different families were screened for their anti-lipase activity, using a radioactive method. On evaluating the results, methanolic extracts of three plants namely, Eriochloa villosa (Thunb.) Kunth, Orixa japonica Thunb. and Setaria italica (L.) Palib., exhibited strong in vitro anti-lipase activity (above 80%). These plants will be studied further to elucidate the structure and chemical properties of the active compound responsible for anti-lipase action.
为了从天然来源中寻找新的胰腺脂肪酶（三酰甘油脂肪酶，EC 3.1.1.3）抑制剂，采用放射性方法对75种来自不同科的药用植物进行了抗脂肪酶活性筛选。在评估结果时，三种植物即稗草（Eriochloa villosa (Thunb.) Kunth）、日本常山（Orixa japonica Thunb.）和粟（Setaria italica (L.) Palib.）的甲醇提取物表现出很强的体外抗脂肪酶活性（超过80%）。这些植物将进一步研究，以阐明负责抗脂肪酶作用的活性化合物的结构和化学性质。
