Al-Ghamdi Maryam A, Choudhry Hani, Al-Doghather Huda A, Huwait Etimad H, Kumosani Taha A, Moselhy Said S
Department of Biochemistry, Faculty of Science, King Abdulaziz University (POBox.80203), Jeddah, Saudi Arabia.
Experimental Biochemistry Unit, king Fahd Medical Research Center, KAU.
Afr J Tradit Complement Altern Med. 2016 Nov 23;14(1):272-277. doi: 10.21010/ajtcam.v14i1.29. eCollection 2017.
Body overweight and obesity were considered as a risk factor for many systemic diseases as diabetic hypertension, cardiovascular diseases, and some cancers. The lipoic acid and Co Q are considered as coenzymes needed for enhancement metabolic rate. The goal of this study is to evaluate the anti-obese effect of lipoic acid alone or combined with Co-Q in rats.
Ninety male albino rats (100-150g) were used in this study, divided into six groups (15 each). Group I: Normal rats fed normal diet. Group II: Rats fed high fat diet (HFD). Group III: Rats fed HFD were given lipoic acid (10 μg/kg b w/day) intra-gastric by stomach tube. Group IV: Rats fed HFD were given Co-Q (10 μg/kg b.w/day) intra-gastric. Group V: Rats fed HFD were given lipoic acid (50 mg/kg b w/day) and Co-Q (10 μg/kg b. w/day). Group VI: Rats were given orlistat intra-gastric (10 mg/kg b w/day) as positive control for 6 weeks. Serum was subjected for determination of lipid profile, liver function tests atherogenic factor and lipoprotein lipase.
It was found that treatment with lipoic acid or Co-Q or combined showed increase in the activity of lipoprotein lipase ( < 0.001) and reduction of atherogenic effect and obesity index ( <0.001). The effect of combined gives good results than orlistat or individual treatment.
lipoic acid combined with Co-Q increase fat oxidation and prevent fat accumulation. The consumption of lipoic acid daily promotes fat oxidation and prevents its accumulation in visceral tissues. Further studies should be carried out to examine the mechanistic signals of these nutrients that helps in weight management.
身体超重和肥胖被认为是许多全身性疾病的危险因素，如糖尿病性高血压、心血管疾病和某些癌症。硫辛酸和辅酶Q被认为是提高代谢率所需的辅酶。本研究的目的是评估硫辛酸单独或与辅酶Q联合对大鼠的抗肥胖作用。
本研究使用90只雄性白化大鼠（100 - 150克），分为六组（每组15只）。第一组：喂食正常饮食的正常大鼠。第二组：喂食高脂饮食（HFD）的大鼠。第三组：喂食HFD的大鼠通过胃管给予硫辛酸（10微克/千克体重/天）。第四组：喂食HFD的大鼠通过胃管给予辅酶Q（10微克/千克体重/天）。第五组：喂食HFD的大鼠给予硫辛酸（50毫克/千克体重/天）和辅酶Q（10微克/千克体重/天）。第六组：大鼠通过胃管给予奥利司他（10毫克/千克体重/天）作为阳性对照，持续6周。对血清进行脂质谱、肝功能测试、致动脉粥样硬化因子和脂蛋白脂肪酶的测定。
发现用硫辛酸或辅酶Q或联合治疗均显示脂蛋白脂肪酶活性增加（<0.001），致动脉粥样硬化作用和肥胖指数降低（<0.001）。联合治疗的效果比奥利司他或单独治疗更好。
硫辛酸与辅酶Q联合可增加脂肪氧化并防止脂肪堆积。每日摄入硫辛酸可促进脂肪氧化并防止其在内脏组织中积累。应进一步开展研究以检查这些有助于体重管理的营养素的作用机制信号。
