Suppr超能文献

氟伐他汀对非甾体抗炎药诱导的大鼠回肠溃疡形成的抑制作用。

Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug.

作者信息

Hagiwara Mari, Kataoka Keiko, Arimochi Hideki, Kuwahara Tomomi, Nakayama Haruyuki, Ohnishi Yoshinari

机构信息

Department of Molecular Bacteriology, Graduate School of Medicine, The University of Tokushima, Tokushima 770-8503, Japan.

出版信息

World J Gastroenterol. 2005 Feb 21;11(7):1040-3. doi: 10.3748/wjg.v11.i7.1040.

DOI:10.3748/wjg.v11.i7.1040
PMID:15742411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4250768/
Abstract

AIM

Nonsteroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage as one of their side effects in humans and experimental animals. Lipid peroxidation plays an important role in NSAID-induced ulceration. The aim of this study was to investigate the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on the ulceration in small intestines of rats.

METHODS

The effects of three HMG-CoA reductase inhibitors, fluvastatin, pravastatin and atorvastatin on ileal ulcer formation in 5-bromo-2-(4-fluorophenyl)-3-(4- methylsulfonylphenyl) thiophene (BFMeT)-treated rats were examined. Antioxidative activity of the inhibitors was measured by a redox-linked colorimetric method.

RESULTS

Fluvastatin, which was reported to have antioxidative activity, repressed the ileal ulcer formation in rats treated with BFMeT an NSAIDs. However, the other HMG-CoA reductase inhibitors (pravastatin and atorvastatin) did not repress the ileal ulcer formation. Among these HMG-CoA reductase inhibitors, fluvastatin showed a significantly stronger reducing power than the others (pravastatin, atorvastatin).

CONCLUSION

Fluvastatin having the antioxidaitive activity suppresses ulcer formation in rats induced by NSAIDs.

摘要

目的

非甾体抗炎药（NSAIDs）在人类和实验动物中会导致胃肠道损伤，这是其副作用之一。脂质过氧化在NSAIDs诱导的溃疡形成中起重要作用。本研究的目的是探讨3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂对大鼠小肠溃疡形成的抑制作用。

方法

研究了三种HMG-CoA还原酶抑制剂氟伐他汀、普伐他汀和阿托伐他汀对5-溴-2-（4-氟苯基）-3-（4-甲基磺酰苯基）噻吩（BFMeT）处理的大鼠回肠溃疡形成的影响。通过氧化还原偶联比色法测定抑制剂的抗氧化活性。

结果

据报道具有抗氧化活性的氟伐他汀可抑制BFMeT（一种NSAIDs）处理的大鼠的回肠溃疡形成。然而，其他HMG-CoA还原酶抑制剂（普伐他汀和阿托伐他汀）并未抑制回肠溃疡形成。在这些HMG-CoA还原酶抑制剂中，氟伐他汀的还原能力明显强于其他药物（普伐他汀、阿托伐他汀）。

结论

具有抗氧化活性的氟伐他汀可抑制NSAIDs诱导的大鼠溃疡形成。

相似文献

1
Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug.
World J Gastroenterol. 2005 Feb 21;11(7):1040-3. doi: 10.3748/wjg.v11.i7.1040.
2
Culture supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis repress ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug by suppressing unbalanced growth of aerobic bacteria and lipid peroxidation.
Microbiol Immunol. 1998;42(5):347-55. doi: 10.1111/j.1348-0421.1998.tb02294.x.
3
Inhibitory effects of fluvastatin and its metabolites on hydrogen peroxide-induced oxidative destruction of hemin and low-density lipoprotein.
Biol Pharm Bull. 2000 Jul;23(7):873-8. doi: 10.1248/bpb.23.873.
4
Protective effects of a culture supernatant of Lactobacillus acidophilus and antioxidants on ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug.
Microbiol Immunol. 1998;42(11):745-53. doi: 10.1111/j.1348-0421.1998.tb02348.x.
5
HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins.
Exp Toxicol Pathol. 2000 May;52(2):145-8. doi: 10.1016/S0940-2993(00)80107-4.
6
Fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, scavenges free radicals and inhibits lipid peroxidation in rat liver microsomes.
Eur J Pharmacol. 1998 Nov 13;361(1):143-9. doi: 10.1016/s0014-2999(98)00692-x.
7
Lipophilic HMG-CoA reductase inhibitors increase myocardial stunning in dogs.
J Cardiovasc Pharmacol. 2000 Feb;35(2):256-62. doi: 10.1097/00005344-200002000-00012.
8
Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes.
J Pharm Pharmacol. 2001 Feb;53(2):227-32. doi: 10.1211/0022357011775244.
9
Statins upregulate cystathionine γ-lyase transcription and H2S generation via activating Akt signaling in macrophage.
Pharmacol Res. 2014 Sep;87:18-25. doi: 10.1016/j.phrs.2014.06.006. Epub 2014 Jun 18.
10
Inhibition of cholesterol synthesis ex vivo and in vivo by fluvastatin, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Experientia. 1995 Mar 15;51(3):223-6. doi: 10.1007/BF01931101.

引用本文的文献

1
Prevention and management of non-steroidal anti-inflammatory drugs-induced small intestinal injury.
World J Gastroenterol. 2011 Nov 14;17(42):4647-53. doi: 10.3748/wjg.v17.i42.4647.
2
Potential role of statins on wound healing: review of the literature.
Int Wound J. 2012 Jun;9(3):238-47. doi: 10.1111/j.1742-481X.2011.00888.x. Epub 2011 Nov 4.

本文引用的文献

1
Comparison of nitric oxide-releasing NSAID and vitamin C with classic NSAID in healing of chronic gastric ulcers; involvement of reactive oxygen species.
Med Sci Monit. 2001 Jul-Aug;7(4):592-9.
2
Inhibitory effects of fluvastatin and its metabolites on hydrogen peroxide-induced oxidative destruction of hemin and low-density lipoprotein.
Biol Pharm Bull. 2000 Jul;23(7):873-8. doi: 10.1248/bpb.23.873.
3
Inhibitory effects of tea extracts on the mutagenicity of 1-methyl-1, 2,3,4-tetrahydro-beta-carboline-3-carboxylic acid on treatment with nitrite in the presence of ethanol.
Food Chem Toxicol. 2000 Jan;38(1):7-13. doi: 10.1016/s0278-6915(99)00121-0.
4
Selective inhibition of formyl-methionyl-leucyl-phenylalanine (fMLF)-dependent superoxide generation in neutrophils by pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.
Biochem Pharmacol. 1999 Dec 15;58(12):1975-80. doi: 10.1016/s0006-2952(99)00260-9.
5
Superoxide anion scavenging properties of fluvastatin and its metabolites.
Chem Pharm Bull (Tokyo). 1999 Oct;47(10):1477-80. doi: 10.1248/cpb.47.1477.
6
An in vitro study of the hydroxyl radical scavenging property of fluvastatin, and HMG-CoA reductase inhibitor.
Chem Pharm Bull (Tokyo). 1999 Jul;47(7):1010-2. doi: 10.1248/cpb.47.1010.
7
Role of antioxidants in gastric mucosal damage induced by indomethacin in rats.
Methods Find Exp Clin Pharmacol. 1998 Dec;20(10):849-54. doi: 10.1358/mf.1998.20.10.487540.
8
Atherosclerosis--an inflammatory disease.
N Engl J Med. 1999 Jan 14;340(2):115-26. doi: 10.1056/NEJM199901143400207.
9
Protective effects of a culture supernatant of Lactobacillus acidophilus and antioxidants on ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug.
Microbiol Immunol. 1998;42(11):745-53. doi: 10.1111/j.1348-0421.1998.tb02348.x.
10
Fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, scavenges free radicals and inhibits lipid peroxidation in rat liver microsomes.
Eur J Pharmacol. 1998 Nov 13;361(1):143-9. doi: 10.1016/s0014-2999(98)00692-x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验