World J Gastroenterol. 2011 Nov 14;17(42):4647-53. doi: 10.3748/wjg.v17.i42.4647.
Non-steroidal anti-inflammatory drug (NSAID)-induced small bowel injury is a topic that deserves attention since the advent of capsule endoscopy and balloon enteroscopy. NSAID enteropathy is common and is mostly asymptomatic. However, massive bleeding, stricture, or perforation may occur. The pathogenesis of small intestine injury by NSAIDs is complex and different from that of the upper gastrointestinal tract. No drug has yet been developed that can completely prevent or treat NSAID enteropathy. Therefore, a long-term randomized study in chronic NSAID users is needed.
非甾体抗炎药(NSAID)诱导的小肠损伤是一个值得关注的话题,自从胶囊内镜和气囊式小肠镜问世以来。NSAID 肠病很常见,且大多无症状。然而,也可能发生大出血、狭窄或穿孔。NSAIDs 引起的小肠损伤的发病机制复杂,与上消化道不同。目前尚无药物能完全预防或治疗 NSAID 肠病。因此,需要对慢性 NSAID 使用者进行长期的随机研究。