López José M, Carrasco Carmen M A
Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile.
Rev Med Chil. 2004 Dec;132(12):1527-31. doi: 10.4067/s0034-98872004001200012.
Pseudohypoparathyroidism is characterized by a resistance to parathormone, with variable phenotypical and biochemical manifestations. Its diagnosis is difficult. We report a 28 year old male presenting with a hypokalemic periodic paralysis. His serum PTH was elevated to 1,343 and 1,101 pg/ml with concomitant hypocalcemia of 7.9 and 6.7 mg/dl. Twenty four hour urinary calcium and serum 25 hydroxy vitamin D were normal. Bone mineral density was normal. The patient was managed with calcitriol in doses of 1 to 2 microg/d, associated to calcium 2 g/day. Serum calcium levels and PTH normalized after two months and six months of treatment respectively.
假性甲状旁腺功能减退症的特征是对甲状旁腺激素有抵抗,伴有多种表型和生化表现。其诊断较为困难。我们报告了一名28岁男性,患有低钾性周期性麻痹。他的血清甲状旁腺激素升高至1343和1101 pg/ml,同时伴有低钙血症,血钙水平分别为7.9和6.7 mg/dl。24小时尿钙和血清25-羟维生素D正常。骨密度正常。该患者接受骨化三醇治疗,剂量为1至2μg/d,并联合每日2g钙。治疗两个月和六个月后,血清钙水平和甲状旁腺激素分别恢复正常。