一种来自山竹科植物（Garcinia bancana MIQ.）的抗菌联苯衍生物。

An antibacterial biphenyl derivative from Garcinia bancana MIQ.

作者信息

Rukachaisirikul Vatcharin, Naklue Wanpen, Sukpondma Yaowapa, Phongpaichit Souwalak

机构信息

Department of Chemistry, Faculty of Science, Prince of Songkla University, Thailand.

出版信息

Chem Pharm Bull (Tokyo). 2005 Mar;53(3):342-3. doi: 10.1248/cpb.53.342.

DOI:10.1248/cpb.53.342

PMID:15744113

Abstract

From the methanol extract of the twigs and leaves of Garcinia bancana MIQ., one new biphenyl derivative (1), was isolated and characterized along with nine known compounds; garcinol, isogarcinol, (-)-mellein, 8-hydroxy-6-methoxy-3-n-pentylisocoumarin, blumenol C O-beta-D-glucoside, quercetin 3-O-alpha-L-rhamnoside, kaemferol 3-O-alpha-L-rhamnoside, lupeol and stigmasterol. Their structures were determined by analysis of 1D and 2D NMR data and comparison of spectral data and physical data with those previously reported. The antibacterial activity against methicillin-resistant Staphylococcus aureus was evaluated. Garcinol showed the lowest minimum inhibition concentration (MIC) at 16 microg/ml while compound 1 exhibited weaker activity with MIC value of 64 microg/ml.

摘要

从山竹子（Garcinia bancana MIQ.）的枝叶甲醇提取物中，分离得到一个新的联苯衍生物（1），并鉴定出9个已知化合物，分别为藤黄醇、异藤黄醇、（-）-水合氧化橙皮内酯、8-羟基-6-甲氧基-3-正戊基异香豆素、布鲁门醇C O-β-D-葡萄糖苷、槲皮素3-O-α-L-鼠李糖苷、山柰酚3-O-α-L-鼠李糖苷、羽扇豆醇和豆甾醇。通过一维和二维核磁共振数据的分析以及光谱数据和物理数据与先前报道数据的比较确定了它们的结构。评估了对耐甲氧西林金黄色葡萄球菌的抗菌活性。藤黄醇的最低抑菌浓度（MIC）最低，为16微克/毫升，而化合物1的活性较弱，MIC值为64微克/毫升。