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作为强迫症动物模型的精神兴奋剂诱导行为：对强迫仪式形式的行为学研究方法。

Psychostimulant-induced behavior as an animal model of obsessive-compulsive disorder: an ethological approach to the form of compulsive rituals.

作者信息

Eilam David, Szechtman Henry

机构信息

Department of Zoology, Tel-Aviv University, Israel.

出版信息

CNS Spectr. 2005 Mar;10(3):191-202. doi: 10.1017/s109285290001004x.

DOI:10.1017/s109285290001004x
PMID:15744221
Abstract

Rats treated chronically with the D2/D3 dopamine receptor agonist quinpirole show a pattern of behavior that meets a set of ethologically derived criteria of compulsive behavior in obsessive-compulsive disorder (OCD). Moreover, in both quinpirole-treated rats and OCD patients, the structure of compulsive rituals appear similar in being composed of relatively few motor acts that are organized in a flexible yet recurrent manner. In addition, the development of compulsive behavior in quinpirole-treated rats is attenuated by the OCD pharmacotherapeutic drug clomipramine. These similarities support the validity of quinpirole-treated rats as a psychostimulant-induced animal model of OCD. Considering that the induction of compulsive behavior in the rat model involves chronic hyperstimulation of dopamine receptors, this raises the possibility that dopaminergic mechanisms may play a role in OCD, at least in some subtypes of this disorder.

摘要

长期接受D2/D3多巴胺受体激动剂喹吡罗治疗的大鼠表现出一种行为模式，这种行为模式符合一组源自动物行为学的强迫症（OCD）强迫行为标准。此外，在接受喹吡罗治疗的大鼠和OCD患者中，强迫仪式行为的结构似乎相似，都是由相对较少的运动行为组成，这些行为以灵活但重复的方式组织起来。此外，OCD药物治疗药物氯米帕明可减弱喹吡罗治疗大鼠强迫行为的发展。这些相似之处支持了喹吡罗治疗大鼠作为精神兴奋剂诱导的OCD动物模型的有效性。鉴于大鼠模型中强迫行为的诱导涉及多巴胺受体的慢性过度刺激，这增加了多巴胺能机制可能在OCD中起作用的可能性，至少在该疾病的某些亚型中如此。