Aliotta Jason M, Passero Michael, Meharg Joseph, Klinger James, Dooner Mark S, Pimentel Jeffrey, Quesenberry Peter J
Roger Williams Medical Center, Center for Stem Cell Biology, Providence, RI 02908, USA.
J Cell Physiol. 2005 Sep;204(3):725-41. doi: 10.1002/jcp.20318.
Adult stem cells are likely to have much more versatile differentiation capabilities than once believed. Numerous studies have appeared over the past decade demonstrating the ability of adult stem cells to differentiate into a variety of cells from non-hematopoietic organs, including the lung. The goal of this review is to provide an overview of the growth factors which are thought to be involved in lung development and disease, describe the cells within the lung that are believed to replace cells that have been injured, review the studies that have demonstrated the transformation of bone marrow-derived stem cells into lung cells, and describe potential clinical applications with respect to human pulmonary disease.
成体干细胞可能具有比以往认为的更为广泛的分化能力。在过去十年中，出现了大量研究，证明成体干细胞能够分化为包括肺在内的非造血器官的多种细胞。本综述的目的是概述被认为参与肺发育和疾病的生长因子，描述肺内被认为可替代受损细胞的细胞，回顾已证明骨髓源性干细胞向肺细胞转化的研究，并描述在人类肺部疾病方面的潜在临床应用。
