University of Texas Medical Branch; Galveston, TX USA.
Organogenesis. 2009 Apr;5(2):57-61. doi: 10.4161/org.5.2.8564.
Before we can realize our long term goal of engineering lung tissue worthy of clinical applications, advances in the identification and utilization of cell sources, development of standardized procedures for differentiation of cells, production of matrix tailored to meet the needs of the lung and design of methods or techniques of applying the engineered tissues into the injured lung environment will need to occur. Design of better biomaterials with the capacity to guide stem cell behavior and facilitate lung lineage choice as well as seamlessly integrate with living lung tissue will be achieved through advances in the development of decellularized matrices and new understandings related to the influence of extracellular matrix on cell behavior and function. We have strong hopes that recent developments in the engineering of conducting airway from decellularized trachea will lead to similar breakthroughs in the engineering of distal lung components in the future.
在我们实现将有临床应用价值的肺组织工程化的长期目标之前，需要在细胞来源的鉴定和利用、细胞分化的标准化程序的开发、适合肺需求的基质的生产以及将工程组织应用于损伤肺环境的方法或技术的设计方面取得进展。通过对脱细胞基质的发展和对细胞行为和功能有影响的细胞外基质的新认识，设计出更好的生物材料，使其具有引导干细胞行为和促进肺系选择的能力，并与活肺组织无缝集成，将成为可能。我们非常希望，最近在脱细胞气管构建传导气道方面的进展，将为未来构建远端肺成分方面带来类似的突破。
