Alvarez-Franco M, Reyes-Mugica M, Paller A S
Department of Pediatrics, Children's Memorial Hospital, Northwestern University School of Medicine, Chicago, Illinois.
Pediatr Dermatol. 1992 Mar;9(1):62-5. doi: 10.1111/j.1525-1470.1992.tb00328.x.
Disseminated fusariosis occurred in a pediatric patient with acute lymphocytic leukemia in relapse. The patient had fever and neutropenia, and scattered violaceous papules and vesicles with central erosions that rapidly progressed to generalized, painful, violaceous, papulovesicular lesions with central necrosis. Severe myalgias were associated. The diagnosis was suspected by noting hyphae on a smear of vesicular contents, and confirmed by culture. The clinical course was rapidly fatal despite early institution of amphotericin B therapy. Disseminated Fusarium infection should be suspected in immunocompromised patients with fever and neutropenia who have generalized, eroded, violaceous papules, vesicles, and pustules, particularly with associated myalgias.
播散性镰刀菌病发生在一名复发的急性淋巴细胞白血病儿科患者身上。该患者有发热和中性粒细胞减少症，散在的紫红色丘疹和水疱，中央有糜烂，迅速发展为全身性、疼痛性、紫红色、丘疹水疱性病变，并伴有中央坏死。伴有严重肌痛。通过在水疱内容物涂片上发现菌丝怀疑诊断，并通过培养确诊。尽管早期给予两性霉素B治疗，临床病程仍迅速致命。对于有发热和中性粒细胞减少症、出现全身性、糜烂性、紫红色丘疹、水疱和脓疱，尤其是伴有肌痛的免疫功能低下患者，应怀疑播散性镰刀菌感染。
