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急性淋巴细胞白血病患者发生侵袭性镰刀菌病伴长时间菌血症:病例报告及文献复习。

Invasive fusariosis with prolonged fungemia in a patient with acute lymphoblastic leukemia: case report and review of the literature.

机构信息

Infectious Diseases Division, University Hospitals of Geneva, 24 Rue Micheli-du-Crest, Geneva 14, Switzerland.

出版信息

Int J Infect Dis. 2010 Apr;14(4):e354-6. doi: 10.1016/j.ijid.2009.05.004. Epub 2009 Aug 7.

Abstract

Fusariumspp are rare but important opportunistic pathogens in immunocompromised patients. Disseminated fusarial infections occur mostly in patients with hematologic malignancies with myelosuppressive chemotherapy or in patients with severe immunodeficiency. Although more frequent than Aspergillus fungemia, Fusarium fungemia remains a rare event. We describe the case of a female patient with febrile neutropenia and persistent fungemia due to Fusarium solani, treated with posaconazole and liposomal amphotericin B. A review of the literature for Fusariumspp fungemia was carried out.

摘要

镰刀菌属是免疫功能低下患者中罕见但重要的机会性病原菌。播散性镰刀菌感染主要发生在接受骨髓抑制性化疗的血液系统恶性肿瘤患者或严重免疫缺陷患者中。虽然比曲霉属菌血症更为常见,但 Fusarium 菌血症仍然是一种罕见的事件。我们描述了一例女性中性粒细胞减少性发热患者,因感染 Fusarium solani 而持续发生真菌血症,采用泊沙康唑和脂质体两性霉素 B 进行治疗。我们对镰刀菌属菌血症的文献进行了回顾。

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