Wasiluk Alicja
Department of Neonatology, ul. MC. Sklodowskiej 24a, 15-276 Bialystok, Poland.
Platelets. 2004 Nov;15(7):459-61. doi: 10.1080/09537100410001710281.
Measurements have been made of the antigen density of P-selectin (CD 62P) on the surface of platelets of healthy term newborns in relation to sex and in different umbilical vessels. The effect of thrombin or ADP on the density of CD 62P has been determined. The study was performed in 18 healthy term newborns, 10 girls and eight boys. Dako QIFIKIT was applied to calculate the number of these antigens. No differences were observed in the number of antigens of CD 62P on newborn platelets between the umbilical vein and artery in both sexes. On the other hand, boys demonstrated 31,245 antigens/plt, girls 26,397/plt (P = 0.045). A statistically significant increase in the expression of CD 62P was also observed following activation of thrombin in both sexes and in the umbilical vein and artery. ADP as a weaker agonist demonstrated less changes. A high number of the CD 62P antigens on the platelets of newborns may be interpreted as an effect of increased thrombinogenesis during birth. It can be suggested that this process is more pronounced in boys than girls.
已对健康足月儿血小板表面P-选择素（CD 62P）的抗原密度进行了测量，测量涉及性别以及不同的脐血管。已确定凝血酶或二磷酸腺苷（ADP）对CD 62P密度的影响。该研究在18名健康足月儿中进行，其中10名女孩，8名男孩。使用达科QIFIKIT计算这些抗原的数量。在两性中，脐静脉和动脉的新生儿血小板上CD 62P抗原数量均未观察到差异。另一方面，男孩显示有31,245个抗原/血小板，女孩为26,397个/血小板（P = 0.045）。在两性以及脐静脉和动脉中，凝血酶激活后，还观察到CD 62P表达有统计学意义的增加。作为较弱激动剂的ADP显示出较少变化。新生儿血小板上大量的CD 62P抗原可被解释为出生时凝血酶生成增加的结果。可以认为，这一过程在男孩中比在女孩中更明显。
