Wasiluk Alicja, Mantur Maria, Szczepański Marek, Kemona Halina, Baran Elwira, Kemona-Chetnik Izabela
Department of Neonatology, Medical University of Bialystok, Poland.
Platelets. 2008 May;19(3):236-8. doi: 10.1080/09537100701882046.
Hemostasis in preterm newborns is characterized by low reserve functional capacity with special reference to the presence of such risk factors as asphyxia or infection. Platelets play vitally important role in hemostasis. Expression of CD62P is a marker of stimulated or activated blood platelets. The study involved a group of 16 preterm newborns, five girls and 11 boys. DAKO QIFIKIT was applied to calculate the number of these antigens. The mean CD 62P expression was found to be 23,792 per platelet. Correlation was found between antigen density and gestational age r = 0.954, p = 0.01. Evident deficit of P-selectin on the surface of platelets in preterm newborns may be at least in part responsible for platelet dysfunction, with special reference to interaction between circulating leukocytes and combating infection.
早产新生儿的止血功能特点是储备功能能力低下，尤其是存在窒息或感染等危险因素时。血小板在止血过程中起着至关重要的作用。CD62P的表达是受刺激或活化血小板的标志物。该研究纳入了一组16名早产新生儿，其中5名女孩和11名男孩。使用DAKO QIFIKIT计算这些抗原的数量。发现每个血小板的平均CD 62P表达为23,792。发现抗原密度与胎龄之间存在相关性，r = 0.954，p = 0.01。早产新生儿血小板表面P-选择素明显缺乏可能至少部分导致血小板功能障碍，特别是循环白细胞之间的相互作用和抗感染。
