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经尿道微波热疗治疗良性前列腺增生

Transurethral microwave thermotherapy for benign prostatic hyperplasia.

作者信息

Rubeinstein Jonathan N, McVary Kevin T

机构信息

Department of Urology, Feinberg Medical School, Northwestern University, Chicago, Illinois 60611, USA.

出版信息

Int Braz J Urol. 2003 May-Jun;29(3):251-63. doi: 10.1590/s1677-55382003000300013.

Abstract

Transurethral resection of the prostate (TURP) remains the gold standard for treatment of benign prostatic hyperplasia (BPH). In general, while this procedure is safe, patients require a spinal, epidural, or general anesthesia and often several days of hospital stay; the potential morbidity and mortality limits the use of TURP in high-risk patients. Pharmacotherapy has been recommended as a first-line therapy for all patients with mild to moderate symptoms. Patients are often times enthusiastic if they are offered a one-time method to treat lower urinary tract symptoms secondary to BPH, provided that the method offers reduced risk and allows an efficacy equal to that of medical therapy. One such method is transurethral microwave thermotherapy (TUMT). TUMT involves the insertion of a specially designed urinary catheter with a microwave antenna, which heats the prostate and destroys hyperplastic prostate tissue. TUMT allows the avoidance of general or regional anesthesia, and results in minimal blood loss and fluid absorption. In this review, the authors discussed the current indications and outcome of TUMT, including the history of the procedure, the mechanism of action, the indications for TUMT, the pre-operative considerations, the patient selection, the results in terms of efficacy, by comparing TUMT vs. Sham, TUMT vs. Alpha-blocker and TUMT vs. TURP. Finally, the complications are presented, as well as other uses and future directions of the procedure. The authors concluded that TUMT is a safe and effective minimally invasive alternative to treatment of symptomatic BPH.

摘要

经尿道前列腺电切术(TURP)仍然是治疗良性前列腺增生(BPH)的金标准。一般来说,虽然该手术是安全的,但患者需要进行脊髓、硬膜外或全身麻醉,且通常需要住院几天;潜在的发病率和死亡率限制了TURP在高危患者中的应用。药物治疗已被推荐为所有轻至中度症状患者的一线治疗方法。如果能为患者提供一种一次性治疗BPH继发下尿路症状的方法,且该方法风险降低且疗效与药物治疗相当,患者通常会很感兴趣。经尿道微波热疗(TUMT)就是这样一种方法。TUMT包括插入一根带有微波天线的特殊设计的导尿管,该导尿管会加热前列腺并破坏增生的前列腺组织。TUMT可避免全身或区域麻醉,且失血和液体吸收极少。在这篇综述中,作者讨论了TUMT的当前适应证和结果,包括该手术的历史、作用机制、TUMT的适应证、术前注意事项、患者选择、通过比较TUMT与假手术、TUMT与α受体阻滞剂以及TUMT与TURP得出的疗效结果。最后,介绍了并发症以及该手术的其他用途和未来发展方向。作者得出结论,TUMT是治疗有症状BPH的一种安全有效的微创替代方法。

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