Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.
作者信息
Burton George, Ku Thomas W, Carr Thomas J, Kiesow Terry, Sarisky Robert T, Lin-Goerke Juili, Baker Audrey, Earnshaw David L, Hofmann Glenn A, Keenan Richard M, Dhanak Dashyant
机构信息
GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426-0989, USA.
出版信息
Bioorg Med Chem Lett. 2005 Mar 15;15(6):1553-6. doi: 10.1016/j.bmcl.2005.01.076.
PMID:15745795
Abstract
HTS of the compound collection for inhibition of the HCV RNA dependent RNA polymerase identified two 168 member N-acyl pyrrolidine combinatorial mixture hits. Deconvolution and expansion of these mixtures by solid phase synthesis to establish initial SAR and identify a potent inhibitor is reported.
摘要
Zotero 插件