富勒烯衍生物对人免疫缺陷病毒逆转录酶的抑制作用及对丙型肝炎病毒RNA依赖性RNA聚合酶的抑制作用
Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives.
作者信息
Mashino Tadahiko, Shimotohno Kumiko, Ikegami Noriko, Nishikawa Dai, Okuda Kensuke, Takahashi Kyoko, Nakamura Shigeo, Mochizuki Masataka
机构信息
Kyoritsu University of Pharmacy, Shibakoen 1-5-30, Minato-ku, Tokyo 105-8512, Japan.
出版信息
Bioorg Med Chem Lett. 2005 Feb 15;15(4):1107-9. doi: 10.1016/j.bmcl.2004.12.030.
We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition.
我们检测了阳离子型、阴离子型和氨基酸型富勒烯衍生物对人类免疫缺陷病毒逆转录酶和丙型肝炎病毒RNA依赖性RNA聚合酶的抑制活性。在这些富勒烯衍生物中，氨基酸型富勒烯衍生物对人类免疫缺陷病毒逆转录酶的抑制效果最为显著。
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