胰岛淀粉样多肽（胰淀素）对清醒大鼠外分泌胰腺和胃泌素释放的刺激作用。

Stimulatory effects of islet amyloid polypeptide (amylin) on exocrine pancreas and gastrin release in conscious rats.

作者信息

Funakoshi A, Miyasaka K, Kitani K, Nakamura J, Funakoshi S, Fukuda H, Fujii N

机构信息

National Kyushu Cancer Center, Fukuoka, Japan.

出版信息

Regul Pept. 1992 Mar 19;38(2):135-43. doi: 10.1016/0167-0115(92)90052-v.

DOI:10.1016/0167-0115(92)90052-v

PMID:1574608

Abstract

A rat islet amyloid polypeptide (amylin), 37-residue peptide amide was synthesized by the Fmoc-based solid phase method and the biological activity of synthetic rat amylin on exocrine pancreas was evaluated for the first time in conscious rat. Amylin (1, 10 nmol/kg/h) stimulated pancreatic exocrine secretion and plasma gastrin concentration. CR-1409, a CCK receptor antagonist, did not change amylin-stimulated pancreatic secretion. However, omeprazole (proton pump inhibitor) and atropine inhibited amylin-stimulated pancreatic secretion. This study suggests that amylin may play a role in biological action in the exocrine pancreas possibly mediated by gastric acid hypersecretion.

摘要

采用基于Fmoc的固相法合成了一种37个氨基酸残基的大鼠胰岛淀粉样多肽（胰淀素）肽酰胺，并首次在清醒大鼠中评估了合成大鼠胰淀素对外分泌胰腺的生物活性。胰淀素（1、10 nmol/kg/h）刺激胰腺外分泌和血浆胃泌素浓度。CCK受体拮抗剂CR-1409并未改变胰淀素刺激的胰腺分泌。然而，奥美拉唑（质子泵抑制剂）和阿托品抑制了胰淀素刺激的胰腺分泌。本研究表明，胰淀素可能在外分泌胰腺的生物学作用中发挥作用，可能是由胃酸分泌过多介导的。