胰高血糖素样肽1（7-36）酰胺和胰高血糖素对灌注大鼠胰腺中胰岛淀粉样多肽释放的影响。

Effects of glucagon-like peptide 1 (7-36) amide and glucagon on amylin release from perfused rat pancreas.

作者信息

Inoue K, Hisatomi A, Umeda F, Nawata H

机构信息

Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Horm Metab Res. 1991 Sep;23(9):407-9. doi: 10.1055/s-2007-1003714.

DOI:10.1055/s-2007-1003714

PMID:1743611

Abstract

The effects of glucagon-like peptide 1 (7-36) amide [GLP-1 (7-36) amide] and glucagon on the release of islet amyloid polypeptide (IAPP), or amylin, from the isolated perfused rat pancreas were studied. In the presence of 5.6 mM glucose, GLP-1 (7-36) amide and glucagon stimulated the release of amylin from the perfused pancreas. The infusion of GLP-1 (7-36) amide at a concentration of 10(-9) M elicited a biphasic release of amylin similar to that of insulin. The cumulative output of amylin induced by 10(-9)M GLP-1 (7-36) amide was significantly higher than that by 10(-9)M glucagon (p less than 0.01). The amylin/insulin molar ratios induced by GLP-1 (7-36) amide and glucagon were about 1% and did not differ significantly. These findings suggest that GLP-1 (7-36) amide and glucagon stimulate the release of amylin from the pancreas and that the concomitant secretion of amylin and insulin might contribute to glucose homeostasis.

摘要

研究了胰高血糖素样肽1（7-36）酰胺[GLP-1（7-36）酰胺]和胰高血糖素对从离体灌注大鼠胰腺释放胰岛淀粉样多肽（IAPP）或胰淀素的影响。在5.6 mM葡萄糖存在的情况下，GLP-1（7-36）酰胺和胰高血糖素刺激了灌注胰腺中胰淀素的释放。以10^(-9) M的浓度输注GLP-1（7-36）酰胺引发了类似于胰岛素的胰淀素双相释放。10^(-9) M GLP-1（7-36）酰胺诱导的胰淀素累积输出量显著高于10^(-9) M胰高血糖素诱导的累积输出量（p < 0.01）。GLP-1（7-36）酰胺和胰高血糖素诱导的胰淀素/胰岛素摩尔比约为1%，且无显著差异。这些发现表明，GLP-1（7-36）酰胺和胰高血糖素刺激胰腺释放胰淀素，并且胰淀素和胰岛素的伴随分泌可能有助于葡萄糖稳态。