Wunder D M, Kretschmer R, Bersinger N A
Department of Obstetrics and Gynaecology, University of Berne, Switzerland.
Hum Reprod. 2005 May;20(5):1266-71. doi: 10.1093/humrep/deh767. Epub 2005 Mar 3.
There are only a few studies that have investigated inflammatory processes during ovarian hyperstimulation, with contradictory results especially concerning outcome. The aim of the study was to investigate the inflammatory markers C-reactive protein and leptin in serum and follicular fluid and to correlate these with the outcome.
One hundred and sixty-two gonadotrophin stimulated cycles were evaluated. Serum concentrations of leptin and C-reactive protein were measured at the initiation of stimulation, on the day of hCG administration or the day before, and on the day of oocyte retrieval. They were also determined in the follicular fluid.
Serum leptin and C-reactive protein levels increased significantly during stimulation until the day of oocyte pick up, but following different patterns. After stimulation, they correlated with each other in serum and follicular fluid, but not with estradiol or progesterone concentration, embryo quality, or the pregnancy rate.
Leptin and C-reactive protein levels change significantly during assisted reproductive treatment. In contrast to estradiol they are, however, not a marker of success.
仅有少数研究调查了卵巢过度刺激期间的炎症过程，结果相互矛盾，尤其是在结局方面。本研究的目的是调查血清和卵泡液中的炎症标志物C反应蛋白和瘦素，并将这些与结局相关联。
评估了162个促性腺激素刺激周期。在刺激开始时、注射hCG当天或前一天以及取卵当天测量血清中瘦素和C反应蛋白的浓度。它们也在卵泡液中测定。
在刺激期间直至取卵当天，血清瘦素和C反应蛋白水平显著升高，但遵循不同模式。刺激后，它们在血清和卵泡液中相互关联，但与雌二醇或孕酮浓度、胚胎质量或妊娠率无关。
在辅助生殖治疗期间，瘦素和C反应蛋白水平发生显著变化。然而，与雌二醇不同，它们不是成功的标志物。
