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Evaluation of leptin, interleukin-1beta, tumor necrosis factor-alpha and vascular endothelial growth factor in serum and follicular fluids of women undergoing controlled ovarian hyperstimulation as prognostic markers of ICSI outcome.

作者信息

Nikolettos Nikos, Asimakopoulos Byron, Nicolettos Nikos, Efthimiadou Anna, Mourvati Efthemia, Demirel Cem

机构信息

Laboratory of Physiology, School of Medicine, Democritus University of Thrace, Dragana, 681 00 Alexandroupolis, Greece.

出版信息

In Vivo. 2004 Sep-Oct;18(5):667-73.

PMID:15523910
Abstract

BACKGROUND

Cytokines play an important but controversial role during ovarian folliculogenesis for the development of mature and fertilizable oocytes. In this study, leptin, interleukin-1beta (IL1beta), tumor necrosis factor-alpha (TNFalpha) and vascular endothelial growth factor (VEGF) in serum and follicular fluids (FF) of women undergoing ovarian hyperstimulation were evaluated as prognostic markers of the outcome of intracytoplasmic sperm injection (ICSI) cycles.

MATERIALS AND METHODS

Ninety-five ICSI cycles were included in the study. The cytokines were measured in serum and FF samples with enzyme immunoassay methods.

RESULTS

The cytokine concentrations in serum were not significantly correlated with the cytokine concentrations in FFs. Serum IL1beta was inversely-correlated with the number of retrieved oocytes. Serum TNFalpha was negatively-correlated with fertilization rate. In FFs, TNFalpha was positively-correlated with leptin. Leptin and VEGF in FFs were negatively-associated with pregnancy outcome.

CONCLUSION

Leptin and VEGF concentrations in FFs may serve as prognostic markers of success after ovarian hyperstimulation and ICSI.

摘要

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