眼部细菌分离株对加替沙星及其他局部用抗生素的体外敏感性比较。
Comparison of in vitro susceptibilities of ocular bacterial isolates to gatifloxacin and other topical antibiotics.
作者信息
Kaliamurthy J, Nelson Jesudasan C A, Geraldine P, Parmar P, Kalavathy C M, Thomas P A
机构信息
Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, India.
出版信息
Ophthalmic Res. 2005 May-Jun;37(3):117-22. doi: 10.1159/000084270. Epub 2005 Mar 4.
PURPOSE
To compare the in vitro activity of gatifloxacin with that of other topical antibiotics against fresh bacterial isolates from various types of human ocular infections.
METHODS
A total of 498 strains of ocular bacterial isolates were tested for their susceptibility to gatifloxacin, ofloxacin, ciprofloxacin, norfloxacin, gentamicin, tobramycin, neomycin, chloramphenicol, erythromycin, tetracycline and amikacin.
RESULTS
Ninety-nine percent of gram-positive and 92% of gram-negative bacterial strains were found to be susceptible in vitro to gatifloxacin, whereas lower percentages of gram-positive and gram-negative bacteria were found to be susceptible to other antibiotics.
CONCLUSIONS
In vitro, gatifloxacin exhibits good activity against various bacterial species isolated from different ocular sites. This requires corroboration in the clinical setting.
目的
比较加替沙星与其他局部用抗生素对从各类人类眼部感染中分离出的新鲜细菌菌株的体外活性。
方法
共检测了498株眼部细菌分离株对加替沙星、氧氟沙星、环丙沙星、诺氟沙星、庆大霉素、妥布霉素、新霉素、氯霉素、红霉素、四环素和阿米卡星的敏感性。
结果
发现99%的革兰氏阳性菌和92%的革兰氏阴性菌菌株在体外对加替沙星敏感，而对其他抗生素敏感的革兰氏阳性菌和革兰氏阴性菌的比例较低。
结论
在体外，加替沙星对从不同眼部部位分离出的各种细菌具有良好的活性。这需要在临床环境中得到证实。
Zotero 插件