Badawi Amani E, Moemen Dalia, El-Tantawy Nora L
Department of Ophthalmology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Int J Ophthalmol. 2017 Jan 18;10(1):61-67. doi: 10.18240/ijo.2017.01.10. eCollection 2017.
To analyze the epidemiological, clinical and laboratory findings of infectious keratitis.
A retrospective study on cases of infective keratitis, attended our institution from Mar. 2013 to Feb. 2015, was done at Mansoura Ophthalmic Center, Egypt. Corneal scrapings were performed and processed for direct microscopy and culture in appropriate media using standard laboratory protocols.
Out of 245 patients enrolled for study, 247 corneal scrapings were obtained. Ocular trauma was the most common predisposing factor (51.4%), followed by diabetes mellitus (15.1%). Cultures were positive in 110 scraping samples (44.5%): 45.5% samples had pure fungal infection, 40% had pure bacterial infections and 10% had mixed fungal and bacterial growths. was detected in 5 (4.5%) samples. The most common fungal pathogen was spp. (41%). The most common bacterial isolates were (38.2%) and (21.8%).
Incidence of fungal keratitis is high in our region. Therapeutic approach can initially be based on clinical features and sensitivity/resistance patterns. Microbiological research should direct the antimicrobial treatment. Antibiotic resistance to fluoroquinolones and aminoglycosides is an important consideration.
分析感染性角膜炎的流行病学、临床及实验室检查结果。
在埃及曼苏拉眼科中心，对2013年3月至2015年2月期间在本机构就诊的感染性角膜炎病例进行回顾性研究。采集角膜刮片，按照标准实验室方案在适当培养基中进行直接显微镜检查和培养。
在纳入研究的245例患者中，共获取247份角膜刮片。眼外伤是最常见的诱发因素（51.4%），其次是糖尿病（15.1%）。110份刮片样本培养呈阳性（44.5%）：45.5%的样本为单纯真菌感染，40%为单纯细菌感染，10%为真菌和细菌混合生长。5份（4.5%）样本检测到 。最常见的真菌病原体是 属（41%）。最常见的细菌分离株是 （38.2%）和 （21.8%）。
我们地区真菌性角膜炎的发病率较高。治疗方法最初可基于临床特征和敏感性/耐药模式。微生物学研究应指导抗菌治疗。对氟喹诺酮类和氨基糖苷类抗生素的耐药性是一个重要的考虑因素。
