Chiang Feng-Yu, Wang Ling-Feng, Huang Yin-Feng, Lee Ka-Wo, Kuo Wen-Rei
Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University, Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.
Surgery. 2005 Mar;137(3):342-7. doi: 10.1016/j.surg.2004.09.008.
The aim of this study was to assess the risk of recurrent laryngeal nerve palsy (RLNP) after thyroidectomy with routine identification of the recurrent laryngeal nerve (RLN) during the operation.
The present study was confined to 521 patients, 348 total lobectomies and 178 total thyroidectomies, treated by the same surgeon. Temporary and permanent RLNP rates were analyzed for patient groups with stratification of primary operation for benign thyroid disease, thyroid cancer, Graves' disease, and reoperation. Measurement of the RLNP rate was based on the number of nerves at risk. Twenty-six RLNs in 20 thyroid cancer patients with intentional sacrifice were excluded from analysis.
Forty RLNs (40 patients) developed postoperative RLNP. Complete recovery of RLN function was documented for 35 of the 37 patients (94.6%) whose RLN integrity had been ensured intraoperatively. Recovery from temporary RLNP ranged from 3 days to 4 months (mean, 30.7 days). Overall incidence of temporary and permanent RLNP was 5.1% and 0.9%, respectively. The rates of temporary/permanent RLNP were 4.0/0.2%, 2.0/0.7%, 12.0/1.1%, and 10.8/8.1% for groups classified according to benign thyroid disease, thyroid cancer, Graves' disease, and reoperation, respectively.
Operations for thyroid cancer, Graves' disease, and recurrent goiter demonstrated significantly higher RLNP rates. Invasion of RLN was identified in 19.4% of patients with thyroid cancer. Postoperatively, the RLN recovered in most of the patients without documented nerve damage during the operation. Total lobectomy with routine RLN identification is recommended as a basic procedure in thyroid operations.
本研究旨在评估在甲状腺切除术中常规识别喉返神经(RLN)后发生喉返神经麻痹(RLNP)复发的风险。
本研究纳入了由同一位外科医生治疗的521例患者,其中348例行全叶切除术,178例行全甲状腺切除术。对患有良性甲状腺疾病、甲状腺癌、格雷夫斯病的初次手术患者组以及再次手术患者组的临时和永久性RLNP发生率进行了分析。RLNP发生率的测量基于有风险的神经数量。20例故意牺牲喉返神经的甲状腺癌患者中的26条喉返神经被排除在分析之外。
40条喉返神经(40例患者)出现术后RLNP。在术中确保喉返神经完整的37例患者中,有35例(94.6%)记录到喉返神经功能完全恢复。临时RLNP恢复时间为3天至4个月(平均30.7天)。临时和永久性RLNP的总体发生率分别为5.1%和0.9%。根据良性甲状腺疾病、甲状腺癌、格雷夫斯病和再次手术分类的组中,临时/永久性RLNP发生率分别为4.0/0.2%、2.0/0.7%、12.0/1.1%和10.8/8.1%。
甲状腺癌、格雷夫斯病和复发性甲状腺肿手术的RLNP发生率明显更高。19.4%的甲状腺癌患者发现喉返神经受侵犯。术后,大多数术中未记录神经损伤的患者喉返神经恢复。建议在甲状腺手术中将常规识别喉返神经的全叶切除术作为基本手术方法。