Ng T B, Gao W, Li L, Niu S M, Zhao L, Liu J, Shi L S, Fu M, Liu F
Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Biochem Cell Biol. 2005 Feb;83(1):78-85. doi: 10.1139/o04-100.
The effects of rose-flower extract on antioxidant enzymes were studied. The activities of catalase (CAT) and glutathione peroxidase (GPx) in 9-month-old senescence-accelerated mice (SAM mice) were lower than those in 6-month-old SAM mice. Therefore, 9-month-old SAM mice were the most appropriate targets for treatment with the rose-flower extract. The activities of CAT and GPx in SAM mice treated with rose-flower extract showed a marked increase in whole blood and liver. At the same time, the gene-expression level of CAT and GPx was upregulated in the liver, while malondialdehyde content in liver and brain decreased. Male SAM mice were more sensitive than female SAM mice. The mean and the longest lifespan of SAM mice were longer after treatment with rose-flower extract.
研究了玫瑰花提取物对抗氧化酶的影响。9月龄加速衰老小鼠（SAM小鼠）中过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的活性低于6月龄SAM小鼠。因此，9月龄SAM小鼠是玫瑰花提取物治疗的最合适靶点。用玫瑰花提取物处理的SAM小鼠全血和肝脏中CAT和GPx的活性显著增加。同时，肝脏中CAT和GPx的基因表达水平上调，而肝脏和大脑中的丙二醛含量降低。雄性SAM小鼠比雌性SAM小鼠更敏感。用玫瑰花提取物处理后，SAM小鼠的平均寿命和最长寿命延长。
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