一种含有与DRB115或DRB116等位基因不相关的DRB5基因的新型HLA单倍型。

A novel HLA-haplotype containing a DRB5 gene not associated with DRB115 or DRB116 alleles.

作者信息

Tautz C, Marsh D G, Baur X

机构信息

Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin Ruhr-Universität, Bochum, Germany.

出版信息

Tissue Antigens. 1992 Feb;39(2):91-4. doi: 10.1111/j.1399-0039.1992.tb01913.x.

DOI:10.1111/j.1399-0039.1992.tb01913.x

PMID:1574803

Abstract

In Caucasians, HLA-DR2 haplotypes usually express two DRB genes encoding the DR specificity. The DRB5 genes are in strong linkage disequilibrium with the respective DRB115 or DRB116 alleles. So far, no other DRB1 alleles have been found in association with DRB5 genes. Here, we report evidence for a probably recombinant DRB5 haplotype with a DRB1 allele not specific for DR2. From our results the haplotype DQB10501, DRB10101 and DRB5*0101 seems most likely.

摘要

在白种人中，HLA - DR2单倍型通常表达两个编码DR特异性的DRB基因。DRB5基因与各自的DRB115或DRB116等位基因处于强连锁不平衡状态。到目前为止，尚未发现其他DRB1等位基因与DRB5基因相关联。在此，我们报告了一种可能的重组DRB5单倍型的证据，其携带一个并非DR2特异性的DRB1等位基因。根据我们的结果，单倍型DQB10501、DRB10101和DRB5*0101似乎最有可能。