Halberg Franz, Cornélissen Germaine, Katinas George, Schwartzkopff Othild, Johnson Dana
Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN 55455, USA.
J Circadian Rhythms. 2005 Mar 5;3(1):2. doi: 10.1186/1740-3391-3-2.
We honor Theo Hellbrugge's acclaimed endeavors in the rehabilitation, or rather the prehabilitation of handicapped children. So far, he has focused on obvious handicaps, and we trust that he will include concern for everybody's silent handicaps in the future by screening for abnormal variability inside the physiological range. Therein, we introduce cis- and trans-years, components of transdisciplinary spectra that are novel for biology and also in part for physics. These components have periods, respectively, shorter and longer than the calendar year, with a counterpart in magnetoperiodism. Transyears characterize indices of geomagnetic activity and the solar wind's speed and proton density. They are detected, alone or together with circannuals, in physiology as well as in pathology, as illustrated for sudden cardiac death and myocardial infarction, a finding calling for similar studies in sudden infant death syndrome (SIDS). As transyears can beat with circannuals, and depend on local factors, their systematic mapping in space and time by transdisciplinary chronomics may serve a better understanding of their putative influence upon the circadian system. Longitudinal monitoring of blood pressure and heart rate detects chronome alterations underlying cardiovascular disease risk, such as that of myocardial infarction and sudden cardiac death. The challenge is to intervene in a timely fashion, preferably at birth, an opportunity for pediatricians in Theo Hellbrugge's footsteps.
我们赞扬西奥·赫尔布鲁格在残疾儿童康复，或者更确切地说是在术前康复方面所取得的卓越成就。到目前为止，他一直专注于明显的残疾情况，我们相信他未来会通过筛查生理范围内的异常变异性，将关注点扩展到每个人潜在的隐性残疾上。在此，我们引入了顺年和跨年，它们是跨学科频谱的组成部分，对生物学来说是全新的，对物理学来说在一定程度上也是如此。这些组成部分的周期分别比公历年短和长，在磁周期中有对应物。跨年表征地磁活动指数以及太阳风的速度和质子密度。它们在生理学以及病理学中被单独或与周年节律一起检测到，如在心脏性猝死和心肌梗死中所示，这一发现呼吁对婴儿猝死综合征（SIDS）进行类似研究。由于跨年可以与周年节律同步，并且依赖于局部因素，通过跨学科时间组学对其进行系统的时空映射，可能有助于更好地理解它们对昼夜节律系统的潜在影响。对血压和心率的纵向监测可检测出心血管疾病风险（如心肌梗死和心脏性猝死风险）背后的时间组改变。挑战在于及时进行干预，最好是在出生时，这是追随西奥·赫尔布鲁格脚步的儿科医生的一个机遇。
