多西他赛副作用所致过度流泪的处理

Management of excessive tearing as a side effect of docetaxel.

作者信息

Esmaeli Bita

机构信息

Section of Ophthalmology, Department of Plastic Surgery, Unit 443, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

出版信息

Clin Breast Cancer. 2005 Feb;5(6):455-7. doi: 10.3816/cbc.2005.n.004.

DOI:10.3816/cbc.2005.n.004

PMID:15748466

Abstract

Docetaxel is a highly effective chemotherapeutic agent for metastatic or locally advanced breast cancer as well as other malignancies. One of the side effects of weekly administration of docetaxel is epiphora (excessive tearing) caused by canalicular stenosis and nasolacrimal duct obstruction. This article summarizes experience with epiphora and canalicular stenosis as a side effect of docetaxel and provides specific recommendations for management of this side effect.

摘要

多西他赛是一种用于转移性或局部晚期乳腺癌以及其他恶性肿瘤的高效化疗药物。每周使用多西他赛的副作用之一是泪小管狭窄和鼻泪管阻塞引起的溢泪（流泪过多）。本文总结了多西他赛引起的溢泪和泪小管狭窄的经验，并提供了针对该副作用管理的具体建议。