禁食状态下蓝狐（北极狐）体内的脂联素和肽YY

Adiponectin and peptide YY in the fasting blue fox (Alopex lagopus).

作者信息

Mustonen Anne-Mari, Pyykönen Teija, Nieminen Petteri

机构信息

Department of Biology, University of Joensuu, P.O. Box 111, FIN-80101, Joensuu, Finland.

出版信息

Comp Biochem Physiol A Mol Integr Physiol. 2005 Feb;140(2):251-6. doi: 10.1016/j.cbpb.2005.01.003.

DOI:10.1016/j.cbpb.2005.01.003

PMID:15748866

Abstract

Adiponectin (Acrp30) and peptide YY (PYY) are weight-regulatory hormones participating in the control of energy homeostasis. This study investigated the effects of long-term wintertime fasting on plasma Acrp30 and PYY levels in the carnivorous blue fox, a farm-bred variant of the arctic fox (Alopex lagopus). Plasma Acrp30 and PYY concentrations were determined with radioimmunoassays during a 22-day period of fasting, which led to a 20.3% reduction in body mass of the animals (n=32). Sixteen fed blue foxes served as the control group. Acrp30 and PYY were present in blue fox plasma at similar or lower levels as reported previously for other mammals. Fasting had no acute effects on Acrp30 or PYY concentrations of the blue foxes. However, the Acrp30 levels of the fasted blue foxes were 24%-48% higher than in the fed animals between days 8-22 of fasting. Fasted blue foxes also had 6.2-fold higher plasma PYY concentrations after 15 days of fasting. Acrp30 and PYY seem to play roles in the body weight-regulation of the blue fox during long-term fasting, but their specific functions and physiological significance remain to be determined.

摘要

脂联素（Acrp30）和肽YY（PYY）是参与能量稳态控制的体重调节激素。本研究调查了长期冬季禁食对肉食性蓝狐（北极狐（Alopex lagopus）的一种养殖变种）血浆中Acrp30和PYY水平的影响。在为期22天的禁食期间，用放射免疫分析法测定血浆Acrp30和PYY浓度，禁食导致动物体重下降20.3%（n = 32）。16只喂食的蓝狐作为对照组。蓝狐血浆中的Acrp30和PYY水平与之前报道的其他哺乳动物相似或更低。禁食对蓝狐的Acrp30或PYY浓度没有急性影响。然而，在禁食的第8至22天，禁食蓝狐的Acrp30水平比喂食动物高24% - 48%。禁食15天后，禁食蓝狐的血浆PYY浓度也高出6.2倍。Acrp30和PYY似乎在蓝狐长期禁食期间的体重调节中发挥作用，但其具体功能和生理意义仍有待确定。