Ahluwalia Amrita, Hobbs Adrian J
Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Charterhouse Square, London EC1M 6BQ, UK.
Trends Pharmacol Sci. 2005 Mar;26(3):162-7. doi: 10.1016/j.tips.2005.01.005.
The perceived importance of C-type natriuretic peptide (CNP) in the mammalian vasculature has been raised by its recent identification as an endothelium-derived hyperpolarizing factor (EDHF). This aspect of its biological activity is likely to be significant in the regulation of vascular tone, local blood flow and systemic blood pressure. However, the importance of CNP to cardiovascular homeostasis is likely to extend beyond that of a "hyperpolarizing factor" ; indeed, there is evidence that CNP has a key role in preventing smooth muscle proliferation, leukocyte recruitment and platelet reactivity. As such, endothelium-derived CNP is likely to exert a strong anti-atherogenic influence on blood vessel walls and represent a new therapeutic target in the fight against inflammatory cardiovascular disorders. Moreover, this profile of activity defines a new paradigm for the biological significance of EDHF.
C型利钠肽（CNP）最近被鉴定为一种内皮源性超极化因子（EDHF），这提高了其在哺乳动物血管系统中的重要性。其生物活性的这一方面在调节血管张力、局部血流和全身血压方面可能具有重要意义。然而，CNP对心血管稳态的重要性可能不仅限于“超极化因子”；事实上，有证据表明CNP在防止平滑肌增殖、白细胞募集和血小板反应性方面起关键作用。因此，内皮源性CNP可能对血管壁产生强大的抗动脉粥样硬化影响，并成为对抗炎症性心血管疾病的新治疗靶点。此外，这种活性特征为EDHF的生物学意义定义了一个新的范例。
