Pirner K, Rubbert A, Salinger R, Kalden J R, Manger B
Medizinische Klinik III mit Poliklinik, Universität Erlangen-Nürnberg.
Z Rheumatol. 1992 Jan-Feb;51(1):20-4.
A 33-year-old woman with a 9-year history of psoriasis developed a severe SLE with no signs of visceral involvement during a 3-week exposure to PUVA (psoralen and UVA) therapy. The patient fulfilled the criteria of the American Rheumatism Association (25) for the diagnosis of SLE. She showed dermatological lesions including facial erythema, photo-sensibility arthritis, hematological disorders including leuko-, lympho-, thrombocytopenia, antinuclear antibodies, and dsDNA antibodies. With a therapy that included corticosteroids, chloroquine, and azathioprine the disease could be controlled. The coincidence of a PUVA therapy and the first flare-up of an SLE demonstrates a possible pathogenic role of UV light in SLE.
一名有9年银屑病病史的33岁女性，在接受为期3周的补骨脂素和紫外线A（PUVA）治疗期间，发展为重度系统性红斑狼疮（SLE），且无内脏受累迹象。该患者符合美国风湿病协会（25）制定的SLE诊断标准。她出现了包括面部红斑、光感性关节炎在内的皮肤病变，以及包括白细胞减少、淋巴细胞减少、血小板减少、抗核抗体和双链DNA抗体在内的血液系统疾病。通过包括皮质类固醇、氯喹和硫唑嘌呤的治疗，病情得以控制。PUVA治疗与SLE首次发作的巧合表明紫外线在SLE中可能具有致病作用。
