Akinci E, Colpan A, Bodur H, Balaban N, Erbay A
Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
J Hosp Infect. 2005 Apr;59(4):317-23. doi: 10.1016/j.jhin.2004.09.030.
Intensive care units (ICUs) are high-risk areas for infections caused by antibiotic-resistant bacteria. This study investigated the risk factors for ICU-acquired imipenem-resistant Gram-negative infections. It was conducted prospectively in three surgical ICUs and one medical ICU from April to December 2002. ICU-acquired Gram-negative infections were found in 128 patients. Of these, 42 had imipenem-resistant and 86 had imipenem-sensitive Gram-negative bacteria as the cause of infection. According to the univariate analysis results, hospital stay before ICU admission, hospitalization period before ICU admission, length of ICU stay, surgical ICU stay, surgical operation and previous antibiotic use were significant risk factors for the acquisition of imipenem-resistant infections. In the multivariate analysis, length of ICU stay, surgical operation and previous carbapenem use were independently associated with imipenem resistance.
重症监护病房（ICU）是耐抗生素细菌感染的高风险区域。本研究调查了ICU获得性耐亚胺培南革兰氏阴性菌感染的危险因素。该研究于2002年4月至12月在三个外科ICU和一个内科ICU中进行前瞻性研究。在128例患者中发现了ICU获得性革兰氏阴性菌感染。其中，42例感染的病因是耐亚胺培南革兰氏阴性菌，86例是对亚胺培南敏感的革兰氏阴性菌。根据单因素分析结果，入住ICU前的住院时间、入住ICU前的住院周期、ICU住院时间、外科ICU住院时间、外科手术以及先前使用抗生素是获得耐亚胺培南感染的重要危险因素。在多因素分析中，ICU住院时间、外科手术以及先前使用碳青霉烯类药物与亚胺培南耐药独立相关。
