成人初发急性髓系白血病中第3外显子PTPN11突变的低频率。对173例连续病例的分析。
Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients.
作者信息
Nomdedéu Josep, Carricondo Maria T, Lasa Adriana, Perea Granada, Aventin Ana, Sierra Jorge
出版信息
Haematologica. 2005 Mar;90(3):412-3.
PMID:15749679
Abstract
A total of 173 samples obtained from adult patients with de novo acute myeloid leukemia (AML) were assayed for exon 3 PTPN11 mutations by single strand conformation polymorphism (SSCP) analysis and direct sequencing. Only three monocytic leukemias had point mutations (1.73%).
摘要
通过单链构象多态性（SSCP）分析和直接测序，对从成年初发性急性髓系白血病（AML）患者中获得的总共173份样本进行了PTPN11基因第3外显子突变检测。只有3例单核细胞白血病存在点突变（1.73%）。
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