Roldán Vanessa, González-Conejero Rocío, Marín Francisco, Pineda Javier, Vicente Vicente, Corral Javier
Haematologica. 2005 Mar;90(3):421-3.
We studied 5 functional hemostatic polymorphisms in 281 patients with premature myocardial infarction and in 530 control subjects. The role of these polymorphisms when analyzed independently is small, if any. However, the simultaneous combination of factor XIII and prothrombin polymorphisms exacerbated the risk. (OR=12.12; p=0.028). Moreover, combinations of factor V Leiden with prothrombin, and factor XII with prothrombin polymorphisms were only identified in patients. Our results support the relevance of gene-gene interactions in myocardial infarction.
我们研究了281例早发心肌梗死患者和530例对照者的5种功能性止血多态性。这些多态性单独分析时，即便有作用，其作用也很小。然而，凝血因子XIII和凝血酶原多态性同时存在会增加风险（比值比=12.12；p=0.028）。此外，仅在患者中发现了凝血因子V莱顿突变与凝血酶原多态性以及凝血因子XII与凝血酶原多态性的组合。我们的结果支持基因-基因相互作用在心肌梗死中的相关性。
