Remberger Mats, Sundberg Berit
Haematologica. 2005 Mar;90(3):427-9.
Soluble interleukin-2 receptor (sIL-2R) levels were analyzed in 127 stem-cell transplant recipients. Granulocyte-colony stimulating factor (G-CSF) was given to 57 patients after transplantation. We found an association between G-CSF and increased sIL-2R levels. This indicates increased T-cell activation and may be one reason for the previously found increased incidence of acute graft-versus-host disease in G-CSF-treated patients.
对127例干细胞移植受者的可溶性白细胞介素-2受体（sIL-2R）水平进行了分析。57例患者在移植后接受了粒细胞集落刺激因子（G-CSF）治疗。我们发现G-CSF与sIL-2R水平升高之间存在关联。这表明T细胞活化增加，可能是先前发现的接受G-CSF治疗的患者急性移植物抗宿主病发病率增加的原因之一。
