Gong Sungsam, Yoon Giseok, Jang Insoo, Bolser Dan, Dafas Panos, Schroeder Michael, Choi Hansol, Cho Yoobok, Han Kyungsook, Lee Sunghoon, Choi Hwanho, Lappe Michael, Holm Liisa, Kim Sangsoo, Oh Donghoon, Bhak Jonghwa
Biomatics Lab, Department of BioSystems, KAIST, Daejeon, Korea.
Bioinformatics. 2005 May 15;21(10):2541-3. doi: 10.1093/bioinformatics/bti366. Epub 2005 Mar 3.
Protein Structural Interactome map (PSIMAP) is a global interaction map that describes domain-domain and protein-protein interaction information for known Protein Data Bank structures. It calculates the Euclidean distance to determine interactions between possible pairs of structural domains in proteins. PSIbase is a database and file server for protein structural interaction information calculated by the PSIMAP algorithm. PSIbase also provides an easy-to-use protein domain assignment module, interaction navigation and visual tools. Users can retrieve possible interaction partners of their proteins of interests if a significant homology assignment is made with their query sequences.
蛋白质结构相互作用组图谱(PSIMAP)是一种全局相互作用图谱,它描述了已知蛋白质数据库结构中的结构域 - 结构域和蛋白质 - 蛋白质相互作用信息。它通过计算欧几里得距离来确定蛋白质中可能的结构域对之间的相互作用。PSIbase是一个数据库和文件服务器,用于存储由PSIMAP算法计算出的蛋白质结构相互作用信息。PSIbase还提供了一个易于使用的蛋白质结构域分配模块、相互作用导航和可视化工具。如果通过查询序列进行了显著的同源性分配,用户可以检索他们感兴趣的蛋白质的可能相互作用伙伴。