Chasapis Christos T
Institute of Chemical Engineering Sciences, Foundation for Research & Technology-Hellas (FORTH/ICE-HT), 26504, Patras, Greece.
Mol Biotechnol. 2019 Mar;61(3):221-229. doi: 10.1007/s12033-018-0146-8.
The integration of structural and network-based systems biology is paramount for the improved understanding of how the proteins interact to modulate the behavior of complex biological systems. This review presents the current literature on the computational studies that combine these two scientific fields focusing on two main approaches: network-based analysis of the structure and dynamics of proteins and the in silico reconstruction of protein-protein interaction (PPI) networks or expansion of existed protein interactomes driven by structural annotations. Last, to enrich the current knowledge of the topological properties of the protein structure networks and evaluate the capacity of the public structural annotations of protein domains to predict novel PPIs, further computational analyses, missing so far from the literature, were performed.
整合基于结构和网络的系统生物学对于更好地理解蛋白质如何相互作用以调节复杂生物系统的行为至关重要。本综述介绍了当前关于结合这两个科学领域的计算研究的文献，重点关注两种主要方法：基于网络分析蛋白质的结构和动力学，以及通过结构注释驱动的蛋白质-蛋白质相互作用（PPI）网络的计算机重建或现有蛋白质相互作用组的扩展。最后，为了丰富当前对蛋白质结构网络拓扑特性的认识，并评估蛋白质结构域的公共结构注释预测新PPI的能力，进行了文献中迄今缺少的进一步计算分析。
