Hahn R G
Department of Anaesthesiology, Huddinge University Hospital, Sweden.
Acta Anaesthesiol Scand. 1992 Apr;36(3):241-4. doi: 10.1111/j.1399-6576.1992.tb03457.x.
The blood haemoglobin concentration (B-Hb) was measured repeatedly to reflect dilution or concentration changes of the blood during onset of lumbar epidural anaesthesia in 90 elderly men. With crystalloid volume loading (10 ml.kg-1 b.w.), the decrease in B-Hb was twice as great for those who developed hypotension during the onset of the blockade as for patients whose arterial pressure remained normal (P less than 0.001), both when epidural anaesthesia was induced with plain mepivacaine, and when mepivacaine plus adrenaline was used. In a control group where no fluid loading was performed, there was no consistent change in the haemoglobin level, irrespective of blood pressure reaction to the blockade. The results suggest that crystalloid fluid loading allows an increase in blood volume in epidural-induced hypotension.
对90名老年男性在腰段硬膜外麻醉开始时反复测量血血红蛋白浓度（B-Hb），以反映血液的稀释或浓缩变化。在晶体液负荷（10 ml·kg-1体重）情况下，在阻滞开始时发生低血压的患者，其B-Hb的降低幅度是动脉压保持正常患者的两倍（P<0.001），无论是使用单纯甲哌卡因诱导硬膜外麻醉时，还是使用甲哌卡因加肾上腺素时均如此。在未进行液体负荷的对照组中，无论对阻滞的血压反应如何，血红蛋白水平均无一致变化。结果表明，晶体液负荷可使硬膜外麻醉引起的低血压时血容量增加。
