Löfgren A, Hahn R G
Department of Anaesthesiology, Huddinge University Hospital, Sweden.
Acta Anaesthesiol Scand. 1991 Feb;35(2):170-4. doi: 10.1111/j.1399-6576.1991.tb03267.x.
The short-term effect of epidural anaesthesia (EDA) on the serum potassium (S-K) concentration was studied in 40 elderly men scheduled for minor urological surgery. In Group I, EDA was induced with mepivacaine 2% + adrenaline 1:200,000 (n = 20) and in Group II mepivacaine 2% was used (n = 20). When EDA had been induced, the mean plasma level of adrenaline was tripled in Group I, while it had decreased in Group II. In Group I there was a decrease in the arterial S-K concentration of up to 0.75 mmol.l-1 with a mean of 0.31 mmol.l-1, s.d. 0.20 (P less than 0.001). In Group II, a small but significant decrease of the S-K level was recorded in arterial (0.14 mmol.l-1, s.d. 0.14; P less than 0.001) but not in venous serum. Two-way analysis of variance showed that the addition of adrenaline to the local anaesthetic solution, but not the choice of using arterial or venous serum for analysis, significantly correlated to the lowering of the S-K concentration (P less than 0.001).
对40名计划进行小型泌尿外科手术的老年男性患者，研究了硬膜外麻醉（EDA）对血清钾（S-K）浓度的短期影响。第一组使用2%甲哌卡因+1:200,000肾上腺素诱导EDA（n = 20），第二组使用2%甲哌卡因（n = 20）。诱导EDA后，第一组肾上腺素的平均血浆水平增加了两倍，而第二组则下降。在第一组中，动脉S-K浓度下降高达0.75 mmol.l-1，平均为0.31 mmol.l-1，标准差0.20（P<0.001）。在第二组中，动脉血清中S-K水平有小幅但显著下降（0.14 mmol.l-1，标准差0.14；P<0.001），但静脉血清中未出现下降。双向方差分析表明，在局部麻醉溶液中添加肾上腺素，而非选择使用动脉或静脉血清进行分析，与S-K浓度降低显著相关（P<0.001）。
