Sonne N M, Clausen T G, Valentin N, Halck S, Munksgaard A
Department of Anesthesia, Gentofte University Hospital, Denmark.
Acta Anaesthesiol Scand. 1992 Apr;36(3):250-4. doi: 10.1111/j.1399-6576.1992.tb03459.x.
Total intravenous anaesthesia for direct laryngoscopy was investigated in 40 patients, randomized into four groups of 10 patients each. First, propofol infusion was compared to thiopentone combined with midazolam. Next, a comparison of propofol infusion with methohexitone infusion was undertaken. The propofol group showed significantly lower peroperative blood pressure compared to the thiopentone/midazolam group. The second propofol group required significantly less alfentanil to stabilize the blood pressure, compared to the methohexitone group. Completeness of recovery, assessed by means of a coin counting test, was faster in the propofol group compared to the thiopentone/midazolam group, while no difference could be demonstrated between the second propofol group and the methohexitone group. It is concluded that propofol seems to be superior to both thiopentone/midazolam and methohexitone with respect to the stability of peroperative blood pressure. Concerning recovery, propofol is superior to thiopentone/midazolam, but offers no advantage over methohexitone.
对40例患者进行了直接喉镜检查的全静脉麻醉研究，随机分为四组，每组10例。首先，将丙泊酚输注与硫喷妥钠联合咪达唑仑进行比较。其次，对丙泊酚输注与甲己炔巴比妥输注进行了比较。与硫喷妥钠/咪达唑仑组相比，丙泊酚组术中血压明显较低。与甲己炔巴比妥组相比，第二组丙泊酚组稳定血压所需的阿芬太尼明显较少。通过硬币计数试验评估，丙泊酚组的恢复完整性比硫喷妥钠/咪达唑仑组更快，而第二组丙泊酚组和甲己炔巴比妥组之间没有差异。得出的结论是，在术中血压稳定性方面，丙泊酚似乎优于硫喷妥钠/咪达唑仑和甲己炔巴比妥。在恢复方面，丙泊酚优于硫喷妥钠/咪达唑仑，但与甲己炔巴比妥相比没有优势。
