一名早产儿的碘过载与严重甲状腺功能减退

Iodine overload and severe hypothyroidism in a premature neonate.

作者信息

Khashu Minesh, Chessex Philippe, Chanoine Jean-Pierre

机构信息

Division of Neonatology, Department of Pediatrics, British Columbia Children's Hospital and University of British Columbia, Vancouver BC V6H 3V4, Canada.

出版信息

J Pediatr Surg. 2005 Feb;40(2):E1-4. doi: 10.1016/j.jpedsurg.2004.10.028.

DOI:10.1016/j.jpedsurg.2004.10.028

PMID:15750908

Abstract

Use of iodinated skin disinfectants in the perinatal period can result in significant iodine overload of the neonate and transient hypothyroidism. The authors report a case of unusually severe hypothyroidism requiring L-thyroxine (L-T4) replacement therapy in a premature neonate after prolonged use of iodinated skin disinfectants for a complex skin lesion. Neonatal iodine overload should be minimized, and in cases with significant iodine exposure, thyroid-stimulating hormone should be monitored, especially in preterm neonates who are exquisitely sensitive to the antithyroid effects of iodine excess.

摘要

围产期使用含碘皮肤消毒剂可导致新生儿碘严重过量及短暂性甲状腺功能减退。作者报告了1例早产新生儿在因复杂皮肤损伤长期使用含碘皮肤消毒剂后发生异常严重的甲状腺功能减退，需用左甲状腺素（L-T4）替代治疗的病例。应尽量减少新生儿碘过量情况，对于有大量碘暴露的病例，应监测促甲状腺激素，尤其是对碘过量的抗甲状腺作用极为敏感的早产儿。