Castaing H, Fournet J P, Léger F A, Kiesgen F, Piette C, Dupard M C, Savoie J C
Arch Fr Pediatr. 1979 Apr;36(4):356-68.
Severe iodine-induced hypothyroidism was recently diagnosed in several neonates raising the responsibility of the iodine antiseptic agents routinely used in these patients. Postnatal iodine overload due to cutaneous application of these agents (povidone iodine and fluorescinated alcoholic-iodine solution) was studied in 5 patients. Thyroid function studies were performed in iodine-overload neonates and in control neonates with comparable gestional age. Results indicated strong evidence of cutaneous absorption of iodine from the antiseptic agents used, leading to hypothyroidism in 12 of them. The frequency and the severity of thyroid dysfunction was closely related to the degree of prematurity. Full recovery was observed in all cases after withdrawal of the iodine-containing agents. It is therefore recommended to avoid any postnatal use of iodine preparations in neonates, mainly in preterm infants, and to use iodine antiseptic agents with great caution, when necessary during the neonatal period.
最近在几名新生儿中诊断出严重的碘诱导甲状腺功能减退症，这增加了这些患者常规使用的碘消毒剂的责任。对5名患者进行了研究，以探讨因皮肤应用这些消毒剂（聚维酮碘和荧光素化酒精碘溶液）导致的产后碘过载情况。对碘过载新生儿和胎龄相当的对照新生儿进行了甲状腺功能研究。结果表明，有强有力的证据显示，所使用的消毒剂中的碘可经皮肤吸收，导致其中12名新生儿出现甲状腺功能减退症。甲状腺功能障碍的频率和严重程度与早产程度密切相关。停用含碘制剂后，所有病例均观察到完全康复。因此，建议避免在新生儿尤其是早产儿中产后使用任何碘制剂，在新生儿期必要时，应极其谨慎地使用碘消毒剂。
