Laditka James N, Laditka Sarah B, Cornman Carol B
Office for the Study of Aging, Center for Health Services Policy and Research, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Am J Alzheimers Dis Other Demen. 2005 Jan-Feb;20(1):27-36. doi: 10.1177/153331750502000109.
The purpose of this study was to determine whether persons with Alzheimer's disease (AD) were at greater risk for in-hospital mortality than non-AD patients as a result of poor quality of care. The study focused on six common medical conditions that result in hospital mortality. Using 1995 to 2000 data from New York state (n = 7,021,065), analysts compared mortality risk for individuals with and without AD. Among men, adjusted odds of death were greater for those with AD for gastrointestinal (GI) hemorrhage (+52 percent), congestive heart failure (CHF) (+42 percent), hip fracture (+35 percent), and acute myocardial infarction (AMI) (+30 percent) (all p < .0001). Among women, AD did not affect risks for most conditions. The results of the study show that men with AD are at higher risk of hospital mortality for common medical conditions, which may indicate poor quality of care. Their risk of hospital death was greater than that of men without AD for AMI, CHF, hip fracture, and GI hemorrhage. Their risk was also greater than that of women with AD for CHF, pneumonia, hip fracture, and GI hemorrhage. With the exception of pneumonia, this risk difference notably exceeded the analogous difference between women and men without AD. Hospital staff should be alerted to greater mortality risk for men with AD, as this risk may indicate lower quality of care.
本研究的目的是确定阿尔茨海默病(AD)患者是否因护理质量差而比非AD患者有更高的院内死亡风险。该研究聚焦于导致医院死亡的六种常见病症。分析人员利用1995年至2000年纽约州的数据(n = 7,021,065),比较了有AD和无AD个体的死亡风险。在男性中,患有AD的人在因胃肠道(GI)出血(增加52%)、充血性心力衰竭(CHF)(增加42%)、髋部骨折(增加35%)和急性心肌梗死(AMI)(增加30%)导致死亡的调整后几率更高(所有p < .0001)。在女性中,AD对大多数病症的风险没有影响。研究结果表明,患有AD的男性因常见病症导致院内死亡的风险更高,这可能表明护理质量较差。他们因AMI、CHF、髋部骨折和GI出血导致的医院死亡风险高于无AD的男性。他们因CHF、肺炎、髋部骨折和GI出血导致的风险也高于患有AD的女性。除肺炎外,这种风险差异明显超过了无AD的女性和男性之间的类似差异。医院工作人员应警惕患有AD的男性有更高的死亡风险,因为这种风险可能表明护理质量较低。