Kentera D, Susić D, Zdravković M
Respiration. 1979;37(4):192-6. doi: 10.1159/000194026.
Rats made hypoxic by confinement in hypoxic cages for 4 weeks developed pulmonary hypertension and right ventricular hypertrophy. Treatment with Verapamil or aspirin reduced both chronic hypoxic pulmonary hypertension and the hypertrophy of the right ventricle. The antihypertensive effect of Verapamil is explained by the involvement of the transmembrane calcium flux in pulmonary vascular smooth muscle in the hypoxic vasoconstrictory response. Part of the antihypertensive effect of inhibition of prostaglandin synthesis is attributed to a decrease in packed cell volume produced in hypoxic, aspirin treated rats.
通过在低氧笼中饲养4周造成低氧的大鼠出现了肺动脉高压和右心室肥大。用维拉帕米或阿司匹林治疗可降低慢性低氧性肺动脉高压和右心室肥大。维拉帕米的降压作用是由于跨膜钙通量参与了低氧性血管收缩反应中的肺血管平滑肌活动。抑制前列腺素合成的降压作用部分归因于低氧、服用阿司匹林的大鼠中红细胞压积的降低。
