Kentera D, Susić D, Zdravković M
Basic Res Cardiol. 1984 May-Jun;79(3):375-8. doi: 10.1007/BF01908038.
In Wistar rats, rendered pulmonary hypertensive by chronic confinement in normobaric "hypoxic cages", impairment of transmembrane transport of calcium by Verapamil and blockage of the action of Angiotensin I converting enzyme by Captopril when applied simultaneously did not show an additive effect in reducing the rise of pulmonary artery pressure and decreasing the augmentation of right ventricular mass. Similarly, the action of Verapamil together with decrease of prostaglandin synthetase activity by Aspirin showed no additive effect. Although in this way the results of the present study failed to give substantial support to the idea of the existence of several mediators of hypoxic pulmonary vasoconstriction, they by no means deny this possibility.
在通过常压“缺氧笼”长期限制饲养而导致肺动脉高压的Wistar大鼠中，维拉帕米对钙跨膜转运的损害以及卡托普利对血管紧张素I转换酶作用的阻断，同时应用时在降低肺动脉压升高和减少右心室质量增加方面未显示出相加效应。同样，维拉帕米的作用与阿司匹林降低前列腺素合成酶活性的作用也未显示出相加效应。尽管如此，本研究结果未能为存在多种低氧性肺血管收缩介质的观点提供实质性支持，但这绝不排除这种可能性。
