Okura Masaya, Kagamiuchi Hajime, Tominaga Gyo, Iida Seiji, Fukuda Yasuo, Kogo Mikihiko
The First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan.
J Oral Pathol Med. 2005 Apr;34(4):214-9. doi: 10.1111/j.1600-0714.2005.00304.x.
Regional immune responses with various types of cancer have been studied histopathologically, however, the prognostic value remains conflicting. The aim of this study was to evaluate morphological changes related to lymph node metastasis and the prognostic value for oral cavity squamous cell carcinoma.
With histopathologic whole architecture of 430 lymph nodes, gross area, germinal center (GC) area, paracortical area (PA), and tumor area were measured.
Metastatic node had significantly lower distribution ratio of PA to lymphoarea than that of tumor-free node. GC area was not constantly associated with lymph node metastasis. In Cox multivariate analysis, the mean ratio of PA to gross area/lymphoarea was an independent prognostic factor.
The proportion of PA to gross/lymph area was associated with lymph node metastasis and long-term survival and may be useful in stratification of those patients for a requirement of adjuvant treatments.
已经通过组织病理学研究了各种类型癌症的局部免疫反应，然而，其预后价值仍存在争议。本研究的目的是评估与淋巴结转移相关的形态学变化以及口腔鳞状细胞癌的预后价值。
对430个淋巴结的组织病理学整体结构进行观察，测量其总面积、生发中心（GC）面积、副皮质区（PA）面积和肿瘤面积。
转移淋巴结的PA与淋巴面积的分布比显著低于无肿瘤淋巴结。GC面积与淋巴结转移并非始终相关。在Cox多因素分析中，PA与总面积/淋巴面积的平均比值是一个独立的预后因素。
PA与总/淋巴面积的比例与淋巴结转移和长期生存相关，可能有助于对那些需要辅助治疗的患者进行分层。
