Oral Pathology, School of Dentistry and Dental Hospital, University of Liverpool, Liverpool, UK.
Eur Arch Otorhinolaryngol. 2013 May;270(5):1581-92. doi: 10.1007/s00405-012-2170-9. Epub 2012 Sep 15.
The superior prognostic value offered by routine histopathological staging of neck dissections, as compared to clinical staging using palpation and modern imaging techniques, is well established in the literature concerning the management of squamous cell carcinoma of the head and neck. In this review, we discuss the definitions and criteria used in standardised routine histopathological reporting and explore additional potential nodal prognostic features. In addition, we critically appraise the value of immunohistochemistry, histochemistry, molecular and other non-morphological techniques and suggest tumour and host features that merit further investigations.
在头颈部鳞状细胞癌的治疗中，文献已经充分证实了与临床触诊和现代影像学技术相比，颈部清扫术的常规组织病理学分期在预后预测方面具有更高的价值。在本文中，我们讨论了标准化常规组织病理学报告中使用的定义和标准，并探讨了其他潜在的淋巴结预后特征。此外，我们还批判性地评估了免疫组织化学、组织化学、分子和其他非形态学技术的价值，并提出了值得进一步研究的肿瘤和宿主特征。
